The genus includes 2 or 3 species, which are much sought after by collectors. They form round bodies and are spineless, with flat ribs bearing tubercles with the areoles, each tufted with hairs.

Lophophora Williamsii. Central Mexico to S. Texas. The areoles bear papery tufts. The body of the plant is a glaucous green with a much thickened tap root. Ribs number 7 to 13. The flowers are pale pink, and appear at the centre of the plant. This peculiar plant has for centuries past played a part in the religious ceremonies and dances of certain North American Indian tribes.

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